Talk
Thrombus is a result of blood solidification and you will unusual viscosity on account of barriers affecting its fluidity; that it contributes to the formation of thrombocytes and you can activation regarding blood coagulation basis (8–10). Hence, correcting bloodstream viscosity and you will improving bloodstream coagulation function spiders has an enthusiastic important part regarding protection and you will therapy of DVT.
All of our study showed that having three days and ten days shortly after DVT modeling, hemorheology and coagulation indexes was in fact a knowledgeable throughout the highest-dose folic acid and you may nutritional B12 group. Specific reports has proposed one Hcy is actually a great blood clots-creating agent, and you may large Hcy you’ll result in strong venous thrombosis (14–17). On the other hand, plasma D-dimer might have been proposed for a good forewarning mode to own blood clots and hypercoagulable state (18,19). 10 weeks shortly after DVT acting, we learned that the degree off Hcy and D-dimer improved the absolute most in the highest-serving class.
Thanks to histopathologic examination, i found that ten months once DVT acting the newest higher-dosage and lowest-amount teams showed tall change in the alteration regarding down extremity strong venous thrombosis. Deep venous thrombosis regarding lower extremity with colour Doppler ultrasound diagnosis has some experts, like effortless operation, safeguards and high efficiency, inexpensive, repeatability and head observance, as well as the recognition of associated sores and bleeding possess as much as blood boats (20). Our very own efficiency also showed that once DVT modeling, the latest productive price away from lower extremity deep venous thrombosis remedy for high-amount group are a hundred%. The outcome from color Doppler ultrasound prognosis off DVT corresponded in order to the conclusions in the histopathologic examination. Which confirmed the brand new feasibility and you will energy saving out of colour Doppler ultrasound prognosis to own deep venous thrombosis of the lower extremity.
Inside sumin B12 keeps clear therapeutic effects into the a rabbit design regarding DVT which have hyperhomocysteinemia. The new large-amounts i attempted enhanced some associated attacks, like the degrees of Hcy and you will D-dimer, hemorheology, coagulation means, and you can vein pathology. Complete, these studies contain the use of high doses of folic acidic and you will nutritional B12 to treat DVT.
Recommendations
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