Then, the INTERSALT study, and this noted an optimistic connection amongst the urinary Na + /K + ratio and you can blood circulation pressure reported a loss in analytical dependence on the brand new relationship inside forty two of your own 52 stores just after improvement getting covariates in addition to ages, gender and you can Bmi [thirty two, 33]
At present there is conflicting evidence regarding the potential blood pressure lowering effects of a reduction in urinary Na + /K + excretion. The TAIM randomized control trial in hypertensive participants on a pharmacological intervention reported no significant difference in DBP between the control diet group and a low Na + /high K + diet group during a six month period . Despite several prior studies reporting an association between blood pressure and the urinary Na + /K + ratio there are several limitations to be considered. conducted in hypertensive participants reported a significant reduction in SBP following 4 weeks of modified low sodium high potassium salt intake compared to participants receiving a normal salt intake , yet all participants were receiving a beta blocker, which is not standard first line treatment for hypertension . In addition, a cross-sectional study, the Dallas heart study, which reported an increase in SBP for an increase in the urinary Na + /K + ratio is limited by the modest correlation the use of single morning urine sample . The PURE study reported a strong linear association between estimated Na + /K + ratio and SBP, that was maintained after covariate adjustment, with the greatest SBP observed with the highest estimated K + and lowest estimated K + excretion . Although we observed that a daily K + excretion of <1 g/day is associated with elevated SBP we observed no association between the urinary Na + /K + excretion ratio and SBP at screening or following DASH-dietary intervention in SS or SR participants. In conjunction with the study by Zanetti et al. , our data suggest high Na + and low K + excretion may increase the likelihood of having increased SBP. However, the lack of association between urinary Na + /K + ratio and SBP in our data do not support a urinary Na + /K + molar excretion ratio of 1:1 as a mechanism to lower blood pressure [16, 17].
The present day data has several benefits: (1) The fresh https://www.datingranking.net/cs/colombian-cupid-recenze/ Dash -Sodium demonstration was a very carefully regulated feeding research and compliance try constantly tracked, (2) The latest crossover construction having Na + intervention greet participant’s to serve as their handle and you will decreased inter-person variability, (3) 24-h ambulatory hypertension tracks have been taken, (4) absence of brand new confounding results of antihypertensive mediations, and you will (5) 24-h urine decide to try range. The big limitation of one’s present analysis ‘s the seemingly small decide to try dimensions that have diminished our mathematical ability to find more compact results of urinary Na + , K + , and Na + :K + ratio towards SBP. While we failed to observe an instability into the baseline services, residual confounding within data is achievable.
Good multicenter analysis by Suppa mais aussi al
To close out the current data of your own Dashboard–Salt Demonstration demonstrates weight loss K + supplements isn’t with the all the way down SBP and that this new decrease in the SBP seen pursuing the Dash diet input taken place separately regarding a good reduced amount of the urinary Na + /K + excretion proportion despite the latest sodium susceptibility away from blood circulation pressure. The research don’t contain the establishment from a-1:step 1 molar removal ratio off Na + /K + while the blood circulation pressure minimizing strategy within the Us Ebony and you may non-African Americans and you will keep the DRI recommendation never to recommend daily K + intake assistance. Because of the restrictions of your newest studies and the lingering debate regarding the character of fat loss K + towards the blood circulation pressure future carefully controlled studies are needed to elucidate the potential effect regarding weight reduction K + and you will urinary Na + /K + removal ratio to the blood pressure in hypertensive and you will normotensive SS and you can SR people.