Due to her abilities, she was poached by the mysterious ITS corporation. During her employment, she began development on a revolutionary human/AI transfer program. Alt kept investing heavily in neural processing cyberware to augment her netrunning skills.
Johnny detonated an explosive charge which gave Toshiro the chance to disconnect Alt from her body
Fascinated by the development of artificial intelligence Alt made a breakthrough in the transfer and containment of intelligence – both AI and the human mind. The unnamed program was able to transfer the users mind into the net and explore independent of their existing body. Her employer ITS capitalized on the breakthrough and developed it further into a weapon known as the Soulkiller – Instead of transferring personalities, it imprisoned them.
On , whilst leaving a concert with her boyfriend, she was kidnapped by gangers and Johnny was left for dead. The kidnappers were hired by Toshiro, who wanted Alt to recreate the program for the Arasaka corporation. While captive she rebuilt the software from memory and though watched closely she feared that Arasaka would test it on her, to prevent this she built a fail-safe to ensure that she could make her escape.
Having survived his injuries, a team led by Johnny Silverhand started a riot at the Arasaka complex, with his legion of fans. Fearing the worst, Toshiro used the software on Alt, but before he was successful she managed to fend off the attack, killing the Arasaka netrunner team and incapacitating Toshiro’s bodyguard, Akira, from within the Arasaka mainframe. Johnny killed Toshiro and disconnected Alt’s from the Arasaka mainframe, killing her in the process. Johnny left with her lifeless body, unknowingly leaving her digital form behind.
Alt died in 2013, what was left behind was a digital ghost an AI stuck in Arasaka Tower. in 2023 
, during the Fourth Corporate War. Johnny Silverhand led another assault on the tower, hoping to rescue Alt and bring an end to Arasaka. Johnny managed to save her before he was ambushed by Adam Smasher. During a surprise ambush, Spider Murphy released Alt back onto the Net.
Not long after, Alt’s digital personality contacted Johnny telling him she was in Arasaka Tower, she also told him not to come after her
In the years following the Fourth Corporate War, Alt set up a digital haven for the other victims of Soulkiller. It was rumored to be hidden on a server somewhere in Night City or in the great white north of Canada, but after the bioplague wiped out the population, Ghost Town was established in the ruins of Hong Kong.
In 2077, Alt was still a very powerful entity on the net. A memorial niche to Alt Cunningham can be found at the Columbarium in Night City. V encountered her after being forced to cross the Blackwall by Voodoo Boys; while doing so relived Johnny’s memories of Alt before her physical death in 2013. The hope of the Voodoo Boys was that Alt would reveal herself to a familiar entity from her previous life.
Alt recognized the engram of Johnny’s and brought him and V to a safe place behind Blackwall. She revealed that she is nothing but an image of Alt Cunningham and is not actually her. The rogue AI explains that the engram was transferred to the net during the 2013 raid. However, due to Johnny disconnecting the physical embodiment of Alt Cunningham while she was still in the net, her consciousness was split from the engram leaving her mind stuck in the net while her body and consciousness laid dying in Johnny’s hands.